The heart of the Companions of St. Anthony ministry is the Shrine of St. Anthony. Located in scenic Howard County, Maryland, just 30 miles west of Baltimore, the Shrine of St. Anthony has been home to the Franciscan Friars for over 70 years. In its long life, the Shrine has been home to many friars and has served as a student residence, a house of philosophy, and a novitiate. Since 1991, the Shrine has been home to the Companions of St. Anthony ministries. The Shrine is privileged to house a major relic of St. Anthony, given to them as a gift from their confreres in Padua, Italy. The relic is housed in the chapel at the Shrine of St. Anthony which is open to the public for prayers and reflection.

Operating both within the Shrine and beyond its walls, the friars' ministries include Devotions, Spirituality & Education, and the Prayer partners.